Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride
نویسندگان
چکیده
منابع مشابه
Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride
The directly compressible floating-bioadhesive tablets of tramadol were formulated using varying amounts Carbopol 971P (CP) and hydroxy-propylmethyl cellulose (HPMC), along with other requisite excipients. In vitro drug release profile, floatational characteristics and ex vivo bioadhesive strength using texture analyzer were determined, and systematically optimized using a 3(2) central composit...
متن کاملFormulation development of oral controlled release tablets of hydralazine: optimization of drug release and bioadhesive characteristics.
The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose...
متن کاملFormulation and Optimization of Gastric Bioadhesive Tablets of Diltiazem Hydrochloride using Central Composite Design
Purpose: To develop bioadhesive tablets of diltiazem hydrochloride with a unique combination of bioadhesion and drug release. Method: Tablets were prepared by physical blending of diltiazem hydrochloride with two polymers, viz., carbopol and hydroxylpropyl methyl cellulose in different ratio along with other excipients. A 3 central composite design was employed to optimize the formulations on t...
متن کاملDevelopment of Osmotically Controlled Oral Drug Delivery Systems of Tramadol Hydrochloride: Effect of Formulation Variables on In Vitro Release Kinetics
Aim: Numerous technologies have been used to control the systemic delivery of a pharmacologically active ingredient in a predetermined, predictable, and reproducible manner. One of the most interesting approaches is osmotically controlled oral drug delivery systems. By optimizing formulation and processing parameters, it is possible to develop osmotic systems to deliver drugs of diverse nature ...
متن کاملFormulation Development of Isoxsuprine Hydrochloride Modified Release Matrix Tablets
The objective of the present investigation was to study the effect of critical formulation parameters affecting release of isoxsuprine hydrochloride from matrix tablets using combination of polyethylene oxide (PEO) and dicalcium phosphate (DCP). The powder blend consisting of drug and excipients was analyzed for angle of repose, Carr’s index and Hausner’s ratio. The tablets were prepared by dir...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2010
ISSN: 0036-8709
DOI: 10.3797/scipharm.1001-04